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Summary of the Differences between Rejuran Healer. Eye. HB and S

Summary of the Differences between Rejuran Healer. Eye. HB and S

AB Medical Editorial Team · 2025.07.31 10,416

As we age, our skin gradually loses its vitality, and issues like fine wrinkles, dryness, and decreased elasticity slowly start to appear. Particularly, repeated exposure to UV rays, environmental stress, and unhealthy lifestyle habits accumulate, progressively diminishing the skin's self-recovery ability. When the skin reaches a state where it is difficult to restore its health on its own, skin boosters are gaining attention as a fundamental solution to stimulate the skin's inherent regenerative power.

Among these treatments, Rejuran is one of the prominent treatments. Rejuran is a procedure that helps significantly improve aging and damaged skin by maximizing the skin's self-regenerative ability. In this column, we will delve into the definition of Rejuran, the effects of each product in its lineup, and solutions for pain management.

What is Rejuran?

Rejuran is an injectable skin treatment that involves directly administering highly purified PN (Polynucleotide) extracted from salmon DNA into the dermal layer of the skin. This helps regenerate and repair damaged skin tissue. By activating the skin cells’ natural healing power, Rejuran enhances the skin barrier, improves elasticity and hydration, refines skin texture, and reduces fine wrinkles—ultimately contributing to overall skin health.

Features of Each Rejuran Product Line

Rejuran Healer

Rejuran Healer is the representative Rejuran treatment that contains high-purity PN (Polynucleotide), a key ingredient that induces skin regeneration. It activates skin cell regeneration and collagen production, making it effective in strengthening the overall skin barrier, improving elasticity, moisturizing, refining skin texture, and reducing fine wrinkles. Right after the procedure, you may experience temporary embossing on the epidermis, as well as mild tingling or pain.

Rejuran I (Eye)

Rejuran I is a product specifically developed for the delicate and sensitive skin around the eyes, using a low-viscosity PN (Polynucleotide) formula. It specializes in alleviating dark circles, reducing fine wrinkles around the eyes, addressing under-eye hollowness, evening out skin tone, and restoring elasticity under the eyes. Due to its lower viscosity, injection causes less pain compared to Rejuran Healer. As it is directly injected into a sensitive area, bruising or swelling may occur. After the procedure, excessive stimulation or massage should be avoided, and temporary stinging or pain may be experienced.

Rejuran HB

Rejuran HB is a complex formulation that lowers the concentration of PN (Polynucleotide) components compared to Rejuran Healer, and adds high-molecular-weight hyaluronic acid and Lidocaine, an aesthetic ingredient. It provides regenerative effects along with immediate moisture supply, skin texture improvement, and vitality restoration. Because it offers less pain and is relatively less irritating, it is recommended for those who are new to Rejuran treatments. However, individuals with skin types sensitive to hyaluronic acid may experience swelling or a feeling of warmth, and the duration of embossing (small bumps from injection) may be longer than with Rejuran Healer, requiring caution depending on one's skin condition.

Rejuran S

Rejuran S is a high-density regenerative formula engineered with a high concentration of PN (Polynucleotide) in a high-viscosity design. It is effective in powerfully reconstructing damaged skin tissues, such as deep scars, thick wrinkles, and acne scars, and is characterized by stronger regenerative power compared to other product lines. Due to its high viscosity and injection with a thicker 30-gauge needle, pain and an embossing reaction (small bumps from injection) can be more pronounced. Close observation of the progress is necessary to prevent inflammatory reactions or excessive swelling in localized areas.

Why Higher Viscosity Leads to More Pain, and the Mechanism of Rejuran Pain

The primary reason for pain during Rejuran procedure is the direct injection of highly viscous PN (Polynucleotide) components into the skin's dermal layer. During this process, the skin physically expands, causing temporary pressure and stinging. Especially with high-viscosity products, the increased resistance during injection can lead to a greater perception of pain. Furthermore, the skin's reaction to a foreign substance can temporarily cause inflammatory pain or swelling at the injection site. While products containing local aesthetic ingredients like Lidocaine help reduce pain, the intensity of pain can vary depending on individual skin thickness, sensitivity, and the treated area.

Solutions for Pain During Rejuran Procedure

Rejuran is an effective procedure for skin regeneration, but due to its injection-based nature, many individuals feel burdened by the pain involved. Especially for those with sensitive skin or who are highly pain-sensitive, the procedure itself can be a source of worry.

In such cases, methods like AirNox (non-sleep inhalation anesthesia) or DermaShine (a multi-needle injector that injects medication at consistent intervals and depths) can be effective alternatives. Machine injections administer the substance into the skin at a consistent pressure and speed, which typically results in less pain compared to manual injections. They are also characterized by relatively less bruising, swelling, and embossing (small bumps from injection).

Furthermore, the recovery time after these procedures is shorter, allowing for a quicker return to daily life. The reduced irritation means that even individuals with sensitive skin can expect a more comfortable treatment experience. If you are considering a Rejuran procedure, we recommend discussing these pain-relief methods during your consultation.

Important Tips to Boost Treatment Effects

Rejuran is a highly advanced skin booster that directly acts on the skin's dermal layer to induce regeneration. Therefore, the practitioner's anatomical knowledge and precise technique are extremely important. Since each individual's skin thickness, elasticity, and degree of damage vary, the key is to accurately analyse the individual's skin type and concerns before the procedure, and precisely adjust the depth and amount injected accordingly.

In particular, a customized approach that considers the skin structure, rather than just simple drug administration, is required. Thus, the practitioner's clinical experience and delicate touch will determine the results.

AB Clinic provides an environment that maximizes the regenerative effects of Rejuran. Our dedicated dermatologist team, with extensive clinical experience, directly diagnoses skin conditions and performs customized procedures based on individual skin characteristics and goals. We strictly adhere to the principles of genuine products and precise dosing, and operate under a meticulous and systematic protocol to ensure safe treatment even for sensitive skin. This approach creates the ideal environment to maximize the regenerative effects of Rejuran.

Written by
AB Medical Editorial Team
Medically reviewed by
Bo-Hyun Kwon (DERMATOLOGIST)
Updated on
2026.11.13
Bo-Hyun Kwon

This article is for informational purposes only and does not replace a personal medical consultation.

For more details, we recommend visiting AB Clinic and consulting with our dedicated dermatology specialists. For inquiries about treatment costs and other procedures, please check the link below and leave a consultation request. We'll get back to you as soon as possible.

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